Endocrine Abstracts

Introduction: Children with TPS and/or ICDI represent a diagnostic and management conundrum. Agreed radiological criteria for TPS are lacking.Aims: To longitudinally characterize the neuroradiological features of children presenting with TPS and/or ICDI due to different aetiologies (oncological, inflammatory, idiopathic).Methods: We searched the terms ‘thickened pituitary stalk’ or ‘idiopathic diabetes insipidus&#146...

Background: IGF1 is the biochemical marker of growth as it is supposed to reflect the activity of the GH axis. The usefulness of IGF1 measurements in children under 3 years has not been verified to date.Aim: We analysed the relationship between serum IGF1 concentration and growth velocity (GV) in children under the age of 3 years.Methods: We compared 300 IGF1 concentrations taken in children younger than 3 years with their GV at ti...

Introduction: Thickened pituitary stalk (TPS) and/or idiopathic central diabetes insipidus (ICDI) are rare in childhood, presenting to different (endocrine, oncology, ophthalmology) specialties. In the absence of other diagnostic features, agreed radiological definitions, biopsy (often too dangerous) or consensus management guidance, subsequent surveillance and treatment are uncertain. Cases may remain undiagnosed or evolve over decades.Aims: i) To longi...

Introduction: Craniopharyngiomas are rare, pituitary tumours which, though benign with good survival, carry high neuroendocrine morbidity. Optimum management remains controversial despite a UK consensus strategy (2005).Aim: To study disease- and treatment-related neuroendocrine, visual and cognitive outcomes in our most recent cohort, managed with individualised multidisciplinary decision making to limit hypothalamic morbidity.Pati...

Background: Childhood tumours of the hypothalamic pituitary axis (HPATs) are very rare and hence any single centre experience is limited. Without evidence-based guidance, treatment is individualised on a case basis. Survival rates are high, but at the expense of significant morbidity. Centralised care or wider multi-professional consultation may improve neuroendocrine and visual outcomes.Objective and hypotheses: 1. To facilitate multi-professional dial...